Dr. Lynn Puana Advances Psilocybin Research at PICMI

DENVER, CO, UNITED STATES, October 16, 2026 /CourierPR/ -- Dr. Lynn Puana, founder of Premier Integrative & Cognitive Medical Institute (PICMI) and S&G Labs, is advancing research and clinical care in the realm of psychedelic medicine, particularly focusing on psilocybin. Through a collaborative effort involving PICMI, S&G Labs, and Alan Wu, PhD, at the University of California, San Francisco (UCSF), the team is exploring the biological and cognitive responses associated with psilocybin.

The research aims to understand the potential role of psilocybin in brain health, mental health, and chronic pain management. Dr. Puana's work involves evaluating brain-derived neurotrophic factor (BDNF), pro-BDNF, psilocin pharmacokinetics, and standardized cognitive assessments. By examining these factors, the researchers hope to determine if measurable physiological responses correlate with changes in cognitive performance.

At PICMI in Denver, Dr. Puana leads a comprehensive approach to brain health and mental wellness. This includes medical screening, individualized care planning, preparation and integration, and licensed psilocybin facilitation within Colorado's regulated natural medicine framework. Dr. Puana's extensive experience in internal medicine, interventional pain management, and addiction medicine informs her clinical perspective on chronic pain, trauma, cognitive function, and complex medical conditions.

Dr. Puana's approach emphasizes appropriate patient selection, individualized follow-up, and continued evaluation of outcomes. She views the research as an opportunity to strengthen the scientific foundation of psychedelic medicine and identify questions requiring further investigation. On October 2, 2026, Dr. Puana presented at the Texas Pain Society meeting in Dallas, discussing emerging research on psilocybin and its potential relevance to chronic pain, neuroplasticity, central sensitization, and the psychological dimensions of persistent pain.

Dr. Puana's work also involves documenting patient perspectives through testimonial videos and podcast discussions. These accounts offer insight into patients' experiences while complementing objective outcome measures and controlled clinical research. The findings from this research may help guide future studies, although additional controlled research is necessary to establish clinical effectiveness, safety, and appropriate applications.

Premier Integrative & Cognitive Medical Institute provides integrative, physician-led services focused on brain health, cognitive assessment, and personalized mental wellness in Denver, Colorado. S&G Labs contributes laboratory and analytical expertise to research initiatives examining biological responses associated with emerging treatments. Together with research collaborators, these organizations support efforts to connect scientific investigation, clinical assessment, and patient-centered care. Their shared objective is to advance understanding of complex health conditions through evidence-informed evaluation and continued research.